MGP Database

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MGP001087

Ontology/Pathway Information

Entrez Gene ID2308
Gene Nameforkhead box O1
Gene Symbol FOXO1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 ISS:UniProtKBCcytosol
GO:0005739 ISS:UniProtKBCmitochondrion
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0003682 ISS:UniProtKBFchromatin binding
GO:0051721 ISS:UniProtKBFprotein phosphatase 2A binding
GO:0001078 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0043565 IDA:UniProtKBFsequence-specific DNA binding
GO:0000981 IBA:GO_CentralFsequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000989 IEA:EnsemblFtranscription factor binding transcription factor activity
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0006914 IEA:UniProtKB-KWPautophagy
GO:0001568 IEA:EnsemblPblood vessel development
GO:0001678 ISS:UniProtKBPcellular glucose homeostasis
GO:0070417 ISS:UniProtKBPcellular response to cold
GO:0006974 ISS:UniProtKBPcellular response to DNA damage stimulus
GO:0071455 IDA:UniProtKBPcellular response to hyperoxia
GO:0032869 ISS:UniProtKBPcellular response to insulin stimulus
GO:0071732 ISS:UniProtKBPcellular response to nitric oxide
GO:0034599 ISS:UniProtKBPcellular response to oxidative stress
GO:0009267 IDA:UniProtKBPcellular response to starvation
GO:0031018 TAS:ReactomePendocrine pancreas development
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0045444 ISS:UniProtKBPfat cell differentiation
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 ISS:UniProtKBPinsulin receptor signaling pathway
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0045599 ISS:UniProtKBPnegative regulation of fat cell differentiation
GO:0032873 IDA:BHF-UCLPnegative regulation of stress-activated MAPK cascade
GO:0045892 ISS:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0043065 IMP:UniProtKBPpositive regulation of apoptotic process
GO:0010508 IMP:UniProtKBPpositive regulation of autophagy
GO:0045722 IEA:EnsemblPpositive regulation of gluconeogenesis
GO:0045732 IMP:UniProtKBPpositive regulation of protein catabolic process
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006473 ISS:UniProtKBPprotein acetylation
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:2000505 ISS:UniProtKBPregulation of energy homeostasis
GO:0035947 IEA:EnsemblPregulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
GO:0001659 ISS:UniProtKBPtemperature homeostasis
GO:0006366 IBA:GOCPtranscription from RNA polymerase II promoter
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_13655AKT-mediated inactivation of FOXO1A
REACT_12442AKT phosphorylates targets in the nucleus
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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