MGP Database

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MGP001088

Ontology/Pathway Information

Entrez Gene ID2309
Gene Nameforkhead box O3
Gene Symbol FOXO3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IEA:UniProtKB-SubCellCcytosol
GO:0016020 IEA:EnsemblCmembrane
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0031490 ISS:UniProtKBFchromatin DNA binding
GO:0001047 ISS:UniProtKBFcore promoter binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0043565 IDA:UniProtKBFsequence-specific DNA binding
GO:0000981 IBA:GO_CentralFsequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 IDA:MGIFsequence-specific DNA binding transcription factor activity
GO:0001547 IEA:EnsemblPantral ovarian follicle growth
GO:0034599 ISS:UniProtKBPcellular response to oxidative stress
GO:0030330 IEA:EnsemblPDNA damage response, signal transduction by p53 class mediator
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0097192 IEA:EnsemblPextrinsic apoptotic signaling pathway in absence of ligand
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0042593 IEA:EnsemblPglucose homeostasis
GO:0001544 IEA:EnsemblPinitiation of primordial ovarian follicle growth
GO:0045087 TAS:ReactomePinnate immune response
GO:0000122 IMP:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0001556 IEA:EnsemblPoocyte maturation
GO:0001542 IEA:EnsemblPovulation from ovarian follicle
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0045648 IDA:MGIPpositive regulation of erythrocyte differentiation
GO:0043525 IMP:UniProtKBPpositive regulation of neuron apoptotic process
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006357 ISS:UniProtKBPregulation of transcription from RNA polymerase II promoter
GO:0006417 IDA:UniProtKBPregulation of translation
GO:0006366 IBA:GOCPtranscription from RNA polymerase II promoter
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_12442AKT phosphorylates targets in the nucleus
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_111057Signaling by NODAL
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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