MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001092

Ontology/Pathway Information

Entrez Gene ID2321
Gene Namefms-related tyrosine kinase 1
Gene Symbol FLT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005768 IEA:UniProtKB-SubCellCendosome
GO:0005615 TAS:ProtIncCextracellular space
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0005887 IDA:UniProtKBCintegral component of plasma membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0043235 IDA:MGICreceptor complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0019838 IPI:UniProtKBFgrowth factor binding
GO:0036332 IDA:UniProtKBFplacental growth factor-activated receptor activity
GO:0004714 TAS:ProtIncFtransmembrane receptor protein tyrosine kinase activity
GO:0005021 IDA:UniProtKBFvascular endothelial growth factor-activated receptor activity
GO:0036326 IDA:UniProtKBFVEGF-A-activated receptor activity
GO:0036327 IDA:UniProtKBFVEGF-B-activated receptor activity
GO:0048514 ISS:UniProtKBPblood vessel morphogenesis
GO:0030154 IEA:UniProtKB-KWPcell differentiation
GO:0016477 IMP:UniProtKBPcell migration
GO:0035924 IDA:UniProtKBPcellular response to vascular endothelial growth factor stimulus
GO:0048598 ISS:UniProtKBPembryonic morphogenesis
GO:0002548 IDA:UniProtKBPmonocyte chemotaxis
GO:0001569 IEA:EnsemblPpatterning of blood vessels
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0045766 IMP:UniProtKBPpositive regulation of angiogenesis
GO:0030335 IDA:UniProtKBPpositive regulation of cell migration
GO:0008284 TAS:ProtIncPpositive regulation of cell proliferation
GO:0043410 IDA:UniProtKBPpositive regulation of MAPK cascade
GO:0043406 IDA:UniProtKBPpositive regulation of MAP kinase activity
GO:0043552 IMP:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0014068 IMP:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0010863 IMP:UniProtKBPpositive regulation of phospholipase C activity
GO:0030949 IDA:BHF-UCLPpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0002040 IEA:EnsemblPsprouting angiogenesis
GO:0007169 TAS:ProtIncPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0036323 IDA:UniProtKBPvascular endothelial growth factor receptor-1 signaling pathway
GO:0048010 IDA:UniProtKBPvascular endothelial growth factor receptor signaling pathway
GO:0038084 IDA:GOCPvascular endothelial growth factor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12473Neurophilin interactions with VEGF and VEGFR
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_12583VEGF binds to VEGFR leading to receptor dimerization
REACT_12380VEGF ligand-receptor interactions
SMP Pathway Links
SMP IDDescription
SMP00420Bevacizumab Action Pathway
  logo