MGP Database

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MGP001093

Ontology/Pathway Information

Entrez Gene ID2324
Gene Namefms-related tyrosine kinase 4
Gene Symbol FLT4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IEA:UniProtKB-SubCellCcytoplasm
GO:0005576 IEA:UniProtKB-SubCellCextracellular region
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0043235 IDA:MGICreceptor complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0019838 IPI:UniProtKBFgrowth factor binding
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0004714 IMP:UniProtKBFtransmembrane receptor protein tyrosine kinase activity
GO:0005021 IMP:UniProtKBFvascular endothelial growth factor-activated receptor activity
GO:0048514 ISS:UniProtKBPblood vessel morphogenesis
GO:0035924 IDA:UniProtKBPcellular response to vascular endothelial growth factor stimulus
GO:0001946 IMP:UniProtKBPlymphangiogenesis
GO:0001945 ISS:BHF-UCLPlymph vessel development
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0010595 IMP:UniProtKBPpositive regulation of endothelial cell migration
GO:0001938 IMP:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0046330 IMP:UniProtKBPpositive regulation of JNK cascade
GO:0043410 IMP:UniProtKBPpositive regulation of MAPK cascade
GO:0090037 IMP:UniProtKBPpositive regulation of protein kinase C signaling
GO:0001934 IMP:UniProtKBPpositive regulation of protein phosphorylation
GO:0010575 IMP:UniProtKBPpositive regulation vascular endothelial growth factor production
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0060312 ISS:UniProtKBPregulation of blood vessel remodeling
GO:0002040 ISS:UniProtKBPsprouting angiogenesis
GO:0007169 TAS:ProtIncPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010 IMP:UniProtKBPvascular endothelial growth factor receptor signaling pathway
GO:0038084 IDA:GOCPvascular endothelial growth factor signaling pathway
GO:0001944 ISS:UniProtKBPvasculature development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_12583VEGF binds to VEGFR leading to receptor dimerization
REACT_12380VEGF ligand-receptor interactions
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