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MGP001102

UniProt Annotations

Entry Information
Gene Nameformyl peptide receptor 1
Protein EntryFPR1_HUMAN
UniProt IDP21462
SpeciesHuman
Comments
Comment typeDescription
FunctionHigh affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456). {ECO:0000269|PubMed:10514456, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2161213, ECO:0000269|PubMed:2176894, ECO:0000303|PubMed:10514456, ECO:0000303|PubMed:1712023, ECO:0000303|PubMed:2161213, ECO:0000303|PubMed:2176894}.
InteractionP25098:ADRBK1; NbExp=3; IntAct=EBI-2869495, EBI-3904795; O15264:MAPK13; NbExp=3; IntAct=EBI-2869495, EBI-2116951;
PtmPhosphorylated; which is necessary for desensitization. {ECO:0000269|PubMed:10514456}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2176894, ECO:0000305|PubMed:10514456}; Multi- pass membrane protein {ECO:0000255}.
SubunitInteracts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response. {ECO:0000269|PubMed:15153520}.
Tissue SpecificityNeutrophils.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FPR1ID44328ch19q13.html";
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