MGP Database

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MGP001106

Ontology/Pathway Information

Entrez Gene ID2475
Gene Namemechanistic target of rapamycin (serine/threonine kinase)
Gene Symbol MTOR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0030425 IEA:EnsemblCdendrite
GO:0012505 IDA:UniProtKBCendomembrane system
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0000139 IEA:UniProtKB-SubCellCGolgi membrane
GO:0005765 IDA:UniProtKBClysosomal membrane
GO:0005764 IDA:UniProtKBClysosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0005741 IEA:UniProtKB-SubCellCmitochondrial outer membrane
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005634 IBA:GO_CentralCnucleus
GO:0005942 NAS:UniProtKBCphosphatidylinositol 3-kinase complex
GO:0016605 IEA:UniProtKB-SubCellCPML body
GO:0031931 IDA:UniProtKBCTORC1 complex
GO:0031932 IDA:UniProtKBCTORC2 complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008144 IEA:InterProFdrug binding
GO:0016301 TAS:UniProtKBFkinase activity
GO:0051219 IPI:UniProtKBFphosphoprotein binding
GO:0046983 IBA:GO_CentralFprotein dimerization activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0043022 IEA:EnsemblFribosome binding
GO:0001030 IDA:UniProtKBFRNA polymerase III type 1 promoter DNA binding
GO:0001031 IDA:UniProtKBFRNA polymerase III type 2 promoter DNA binding
GO:0001032 IDA:UniProtKBFRNA polymerase III type 3 promoter DNA binding
GO:0001156 IDA:UniProtKBFTFIIIC-class transcription factor binding
GO:0016049 IDA:UniProtKBPcell growth
GO:0071456 ISS:UniProtKBPcellular response to hypoxia
GO:0031669 ISS:UniProtKBPcellular response to nutrient levels
GO:0000724 IBA:GO_CentralPdouble-strand break repair via homologous recombination
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0007281 IEA:EnsemblPgerm cell development
GO:0040007 NAS:UniProtKBPgrowth
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0010507 ISS:UniProtKBPnegative regulation of autophagy
GO:0045792 IEA:EnsemblPnegative regulation of cell size
GO:0016242 IEA:EnsemblPnegative regulation of macroautophagy
GO:0051534 IEA:EnsemblPnegative regulation of NFAT protein import into nucleus
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0018105 IMP:UniProtKBPpeptidyl-serine phosphorylation
GO:0018107 IEA:EnsemblPpeptidyl-threonine phosphorylation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0016310 IDA:UniProtKBPphosphorylation
GO:0030838 IEA:EnsemblPpositive regulation of actin filament polymerization
GO:0001938 IEA:EnsemblPpositive regulation of endothelial cell proliferation
GO:0010628 IMP:UniProtKBPpositive regulation of gene expression
GO:0010592 IEA:EnsemblPpositive regulation of lamellipodium assembly
GO:0046889 IMP:UniProtKBPpositive regulation of lipid biosynthetic process
GO:0010831 IEA:EnsemblPpositive regulation of myotube differentiation
GO:0050731 IEA:EnsemblPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 IEA:EnsemblPpositive regulation of protein kinase B signaling
GO:0001934 IDA:UniProtKBPpositive regulation of protein phosphorylation
GO:0051496 IEA:EnsemblPpositive regulation of stress fiber assembly
GO:0045945 IMP:UniProtKBPpositive regulation of transcription from RNA polymerase III promoter
GO:0045727 IDA:UniProtKBPpositive regulation of translation
GO:0046777 IDA:MGIPprotein autophosphorylation
GO:0030163 TAS:UniProtKBPprotein catabolic process
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0032956 IMP:UniProtKBPregulation of actin cytoskeleton organization
GO:0043610 IEA:EnsemblPregulation of carbohydrate utilization
GO:0031998 IEA:EnsemblPregulation of fatty acid beta-oxidation
GO:0005979 IEA:EnsemblPregulation of glycogen biosynthetic process
GO:0045859 IEA:EnsemblPregulation of protein kinase activity
GO:0032314 IEA:EnsemblPregulation of Rac GTPase activity
GO:0032095 IEA:EnsemblPregulation of response to food
GO:0043200 IDA:UniProtKBPresponse to amino acid
GO:0007584 NAS:UniProtKBPresponse to nutrient
GO:0006950 IMP:UniProtKBPresponse to stress
GO:0031529 IEA:EnsemblPruffle organization
GO:0007165 NAS:UniProtKBPsignal transduction
GO:0031295 TAS:ReactomePT cell costimulation
GO:0031929 IMP:UniProtKBPTOR signaling
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_120956Cellular responses to stress
REACT_263897Cellular response to heat stress
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_19344Costimulation by the CD28 family
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_264164HSF1-dependent transactivation
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_6964mTORC1-mediated signalling
REACT_6838mTOR signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_456PKB-mediated events
REACT_6836Release of eIF4E
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_6754S6K1-mediated signalling
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_498Signaling by Insulin receptor
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
SMP Pathway Links
SMP IDDescription
SMP00682Leucine Stimulation on Insulin Signaling
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