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MGP001108

UniProt Annotations

Entry Information

Gene Name	centromere protein I
Protein Entry	CENPI_HUMAN
UniProt ID	Q92674
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92674-1; Sequence=Displayed; Name=2; IsoId=Q92674-2; Sequence=VSP_015797; Note=No experimental confirmation available.;
Function	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269\|PubMed:12640463, ECO:0000269\|PubMed:16622420}.
Induction	By follicle-stimulating hormone (FSH).
Ptm	Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation. {ECO:0000269\|PubMed:20212317}.
Similarity	Belongs to the mis6 family. {ECO:0000305}.
Subcellular Location	Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Subunit	Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6. {ECO:0000269\|PubMed:16622419, ECO:0000269\|PubMed:16622420, ECO:0000269\|PubMed:20212317}.