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MGP001118

UniProt Annotations

Entry Information
Gene NameFYN binding protein
Protein EntryFYB_HUMAN
UniProt IDO15117
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=FYB-120; IsoId=O15117-1; Sequence=Displayed; Name=FYB-130; IsoId=O15117-2; Sequence=VSP_042309; Name=3; IsoId=O15117-3; Sequence=VSP_047288, VSP_042309; Note=No experimental confirmation available.;
FunctionActs as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.
InteractionP06241:FYN; NbExp=2; IntAct=EBI-1753267, EBI-515315; Q13094:LCP2; NbExp=5; IntAct=EBI-1753267, EBI-346946; P16333:NCK1; NbExp=3; IntAct=EBI-1753267, EBI-389883; Q86WV1:SKAP1; NbExp=6; IntAct=EBI-1753267, EBI-2477305;
PtmT-cell receptor ligation leads to increased tyrosine phosphorylation. {ECO:0000269|PubMed:18088087, ECO:0000269|PubMed:19690332}.
SimilarityContains 1 SH3 domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000250}.
SubunitPart of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2. Interacts with FASLG. Interacts with EVL. {ECO:0000250, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:10942756, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16461356, ECO:0000269|PubMed:19807924, ECO:0000269|PubMed:9207119, ECO:0000269|PubMed:9671755, ECO:0000269|PubMed:9748251, ECO:0000269|PubMed:9755858}.
Tissue SpecificityExpressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
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