MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001119

Ontology/Pathway Information

Entrez Gene ID2534
Gene NameFYN proto-oncogene, Src family tyrosine kinase
Gene Symbol FYN
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005768 IDA:HGNCCendosome
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0014069 IEA:EnsemblCpostsynaptic density
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0046875 IPI:UniProtKBFephrin receptor binding
GO:0001948 IPI:BHF-UCLFglycoprotein binding
GO:0070851 IPI:UniProtKBFgrowth factor receptor binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004715 NAS:UniProtKBFnon-membrane spanning protein tyrosine kinase activity
GO:0004713 EXP:ReactomeFprotein tyrosine kinase activity
GO:0050798 IEA:EnsemblPactivated T cell proliferation
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0006816 NAS:UniProtKBPcalcium ion transport
GO:0030154 IBA:GO_CentralPcell differentiation
GO:0016477 IBA:GO_CentralPcell migration
GO:0071375 IBA:GO_CentralPcellular response to peptide hormone stimulus
GO:0007417 IBA:GO_CentralPcentral nervous system development
GO:0048813 IEA:EnsemblPdendrite morphogenesis
GO:0050966 IEA:EnsemblPdetection of mechanical stimulus involved in sensory perception of pain
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0007631 TAS:ProtIncPfeeding behavior
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0030900 IEA:EnsemblPforebrain development
GO:0045087 IBA:GO_CentralPinnate immune response
GO:0035556 TAS:ProtIncPintracellular signal transduction
GO:0007612 TAS:ProtIncPlearning
GO:0050900 TAS:ReactomePleukocyte migration
GO:2001240 IEA:EnsemblPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0010629 IEA:EnsemblPnegative regulation of gene expression
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0042177 IEA:EnsemblPnegative regulation of protein catabolic process
GO:0001764 IEA:EnsemblPneuron migration
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0038083 IBA:GO_CentralPpeptidyl-tyrosine autophosphorylation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030168 TAS:ReactomePplatelet activation
GO:0043123 IEA:EnsemblPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010976 IEA:EnsemblPpositive regulation of neuron projection development
GO:0014068 IEA:EnsemblPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:1900182 IEA:EnsemblPpositive regulation of protein localization to nucleus
GO:0006468 NAS:UniProtKBPprotein phosphorylation
GO:0042981 IBA:GO_CentralPregulation of apoptotic process
GO:0042127 IBA:GO_CentralPregulation of cell proliferation
GO:0008360 IEA:EnsemblPregulation of cell shape
GO:0050690 TAS:ReactomePregulation of defense response to virus by virus
GO:0042493 IEA:EnsemblPresponse to drug
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0042110 IBA:GO_CentralPT cell activation
GO:0031295 TAS:ReactomePT cell costimulation
GO:0050852 IDA:UniProtKBPT cell receptor signaling pathway
GO:0007169 IBA:GO_CentralPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032 TAS:ReactomePviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_18266Axon guidance
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_19238CD28 dependent Vav1 pathway
REACT_111155Cell-Cell communication
REACT_12051Cell surface interactions at the vascular wall
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_19344Costimulation by the CD28 family
REACT_19199CRMPs in Sema3A signaling
REACT_19405CTLA4 inhibitory signaling
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_22351DCC mediated attractive signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_264548EPHA-mediated growth cone collapse
REACT_263952EPHB-mediated forward signaling
REACT_264198EPH-ephrin mediated repulsion of cells
REACT_264068EPH-Ephrin signaling
REACT_264047Ephrin signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160274FCGR activation
REACT_12578GAB1 signalosome
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6185HIV Infection
REACT_6288Host Interactions of HIV factors
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_18334NCAM signaling for neurite out-growth
REACT_11068Nef and signal transduction
REACT_23832Nephrin interactions
REACT_22237Netrin-1 signaling
REACT_22384Netrin mediated repulsion signals
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12519PECAM1 interactions
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_1230Platelet Adhesion to exposed collagen
REACT_111225Regulation of KIT signaling
REACT_23787Regulation of signaling by CBL
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_19236Sema3A PAK dependent Axon repulsion
REACT_19279SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
REACT_19271Semaphorin interactions
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_6835The role of Nef in HIV-1 replication and disease pathogenesis
REACT_264464VEGFA-VEGFR2 Pathway
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
  logo