MGP Database

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MGP001120

Ontology/Pathway Information

Entrez Gene ID2535
Gene Namefrizzled class receptor 2
Gene Symbol FZD2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030669 TAS:ReactomeCclathrin-coated endocytic vesicle membrane
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0016021 IBA:GO_CentralCintegral component of membrane
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0004930 IBA:GO_CentralFG-protein coupled receptor activity
GO:0030165 IPI:UniProtKBFPDZ domain binding
GO:0042813 IBA:GO_CentralFWnt-activated receptor activity
GO:0017147 IBA:GO_CentralFWnt-protein binding
GO:0060070 IDA:UniProtKBPcanonical Wnt signaling pathway
GO:0007267 IEA:EnsemblPcell-cell signaling
GO:0090103 IEA:EnsemblPcochlea morphogenesis
GO:0030855 IEA:EnsemblPepithelial cell differentiation
GO:0060022 IEA:EnsemblPhard palate development
GO:0060119 IEA:EnsemblPinner ear receptor cell development
GO:0003149 IEA:EnsemblPmembranous septum morphogenesis
GO:0003150 IEA:EnsemblPmuscular septum morphogenesis
GO:0030182 ISS:UniProtKBPneuron differentiation
GO:0035567 IBA:GO_CentralPnon-canonical Wnt signaling pathway
GO:0003151 IEA:EnsemblPoutflow tract morphogenesis
GO:0090179 IEA:EnsemblPplanar cell polarity pathway involved in neural tube closure
GO:0030825 IMP:BHF-UCLPpositive regulation of cGMP metabolic process
GO:0051091 IDA:BHF-UCLPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0007608 IEA:EnsemblPsensory perception of smell
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264478Asymmetric localization of PCP proteins
REACT_264224beta-catenin independent WNT signaling
REACT_263982Ca2+ pathway
REACT_18372Class B/2 (Secretin family receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_264034disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125Disease
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264199PCP/CE pathway
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_14797Signaling by GPCR
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264533WNT5A-dependent internalization of FZD2, FZD5 and ROR2
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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