MGP Database

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MGP001143

Ontology/Pathway Information

Entrez Gene ID2571
Gene Nameglutamate decarboxylase 1 (brain, 67kDa)
Gene Symbol GAD1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0061202 TAS:ReactomeCclathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0005622 IDA:UniProtKBCintracellular
GO:0005886 TAS:ReactomeCplasma membrane
GO:0012506 NAS:UniProtKBCvesicle membrane
GO:0016595 IEA:EnsemblFglutamate binding
GO:0004351 IDA:UniProtKBFglutamate decarboxylase activity
GO:0030170 IEA:InterProFpyridoxal phosphate binding
GO:0009449 IEA:EnsemblPgamma-aminobutyric acid biosynthetic process
GO:0006538 TAS:UniProtKBPglutamate catabolic process
GO:0006540 TAS:ProtIncPglutamate decarboxylation to succinate
GO:0042136 IEA:UniProtKB-KWPneurotransmitter biosynthetic process
GO:0007269 TAS:ReactomePneurotransmitter secretion
GO:0018352 TAS:UniProtKBPprotein-pyridoxal-5-phosphate linkage
GO:0042493 IEA:EnsemblPresponse to drug
GO:0007268 TAS:ReactomePsynaptic transmission
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_24020GABA synthesis
REACT_23947GABA synthesis, release, reuptake and degradation
REACT_13685Neuronal System
REACT_13723Neurotransmitter Release Cycle
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP001362-Hydroxyglutric Aciduria (D And L Form)
SMP002434-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
SMP00067Aspartate Metabolism
SMP00007Beta-Alanine Metabolism
SMP00175Canavan Disease
SMP00493Carnosinuria, carnosinemia
SMP00351GABA-Transaminase Deficiency
SMP00072Glutamate Metabolism
SMP00385Homocarnosinosis
SMP00339Hyperinsulinism-Hyperammonemia Syndrome
SMP00192Hypoacetylaspartia
SMP00567Succinic semialdehyde dehydrogenase deficiency
SMP00021Taurine and Hypotaurine Metabolism
SMP00492Ureidopropionase deficiency
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