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MGP Database

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MGP001169

UniProt Annotations

Entry Information

Gene Name	guanylate binding protein 1, interferon-inducible
Protein Entry	GBP1_HUMAN
UniProt ID	P32455
Species	Human

Comments

Comment type	Description
Function	Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. {ECO:0000269\|PubMed:22106366}.
Induction	By IFNG/IFN-gamma during macrophage activation, and by TNF-alpha and IL-1beta. {ECO:0000269\|PubMed:17266443}.
Interaction	Self; NbExp=7; IntAct=EBI-2869161, EBI-2869161;
Similarity	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. {ECO:0000305}.
Similarity	Contains 1 GB1/RHD3-type G (guanine nucleotide- binding) domain. {ECO:0000305}.
Subcellular Location	Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor.
Subunit	Homodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP. Can also heterodimerize with other members of the family. {ECO:0000269\|PubMed:10970849, ECO:0000269\|PubMed:16511497, ECO:0000269\|PubMed:21151871}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GBP1ID50147ch1p22.html";