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MGP001170

UniProt Annotations

Entry Information
Gene Nameguanylate binding protein 2, interferon-inducible
Protein EntryGBP2_HUMAN
UniProt IDP32456
SpeciesHuman
Comments
Comment typeDescription
FunctionHydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). {ECO:0000250}.
InductionBy IFNG/IFN-gamma during macrophage activation, and by TNF-alpha and IL-1beta. {ECO:0000269|PubMed:17266443}.
InteractionQ9WMX2:- (xeno); NbExp=2; IntAct=EBI-714388, EBI-6863741;
SimilarityBelongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. {ECO:0000305}.
SimilarityContains 1 GB1/RHD3-type G (guanine nucleotide- binding) domain. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Golgi apparatus membrane; Lipid-anchor.
SubunitHomodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP. Can also heterodimerize with other members of the family. {ECO:0000269|PubMed:21151871}.
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