MGP Database

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MGP001176

Ontology/Pathway Information

Entrez Gene ID2643
Gene NameGTP cyclohydrolase 1
Gene Symbol GCH1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0031410 IDA:UniProtKBCcytoplasmic vesicle
GO:0005829 IDA:UniProtKBCcytosol
GO:0031965 IDA:HPACnuclear membrane
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0043234 IDA:UniProtKBCprotein complex
GO:0005509 IEA:EnsemblFcalcium ion binding
GO:0050662 IEA:EnsemblFcoenzyme binding
GO:0005525 IDA:UniProtKBFGTP binding
GO:0003934 IDA:UniProtKBFGTP cyclohydrolase I activity
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0008270 IDA:UniProtKBFzinc ion binding
GO:0035998 IEA:UniProtKB-UniPathwayP7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042416 IDA:UniProtKBPdopamine biosynthetic process
GO:0006184 IDA:UniProtKBPGTP catabolic process
GO:0008152 IDA:GOCPmetabolic process
GO:0045776 IEA:EnsemblPnegative regulation of blood pressure
GO:0050884 IMP:MGIPneuromuscular process controlling posture
GO:0006809 NAS:UniProtKBPnitric oxide biosynthetic process
GO:0046209 TAS:ReactomePnitric oxide metabolic process
GO:0051000 IDA:UniProtKBPpositive regulation of nitric-oxide synthase activity
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0051260 IDA:UniProtKBPprotein homooligomerization
GO:0042559 IDA:UniProtKBPpteridine-containing compound biosynthetic process
GO:0008217 IMP:UniProtKBPregulation of blood pressure
GO:0014916 IEA:EnsemblPregulation of lung blood pressure
GO:0050999 TAS:ReactomePregulation of nitric-oxide synthase activity
GO:0034341 IDA:UniProtKBPresponse to interferon-gamma
GO:0032496 IDA:UniProtKBPresponse to lipopolysaccharide
GO:0048265 ISS:UniProtKBPresponse to pain
GO:0034612 IDA:UniProtKBPresponse to tumor necrosis factor
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006729 IDA:UniProtKBPtetrahydrobiopterin biosynthetic process
GO:0046654 IEA:InterProPtetrahydrofolate biosynthetic process
GO:0042311 IEA:EnsemblPvasodilation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12389eNOS activation and regulation
REACT_111217Metabolism
REACT_12508Metabolism of nitric oxide
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
SMP Pathway Links
SMP IDDescription
SMP00486Dopa-responsive dystonia
SMP00487Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency
SMP00488Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps)
SMP00489Hyperphenylalaninemia due to dhpr-deficiency
SMP00005Pterine Biosynthesis
SMP00490Segawa syndrome
SMP00491Sepiapterin reductase deficiency
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