MGP Database

MGP001178

Ontology/Pathway Information

Entrez Gene ID	2645
Gene Name	glucokinase (hexokinase 4)
Gene Symbol	GCK
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005884	IEA:Ensembl	C	actin filament
GO:0045180	IEA:Ensembl	C	basal cortex
GO:0005829	TAS:Reactome	C	cytosol
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0030141	IEA:Ensembl	C	secretory granule
GO:0043531	IEA:Ensembl	F	ADP binding
GO:0005524	IDA:UniProtKB	F	ATP binding
GO:0004340	IDA:UniProtKB	F	glucokinase activity
GO:0005536	IDA:UniProtKB	F	glucose binding
GO:0000287	IEA:Ensembl	F	magnesium ion binding
GO:0070509	IEA:Ensembl	P	calcium ion import
GO:0005975	TAS:Reactome	P	carbohydrate metabolic process
GO:0001678	IBA:GO_Central	P	cellular glucose homeostasis
GO:0042149	IEA:Ensembl	P	cellular response to glucose starvation
GO:0032869	ISS:BHF-UCL	P	cellular response to insulin stimulus
GO:0044320	ISS:BHF-UCL	P	cellular response to leptin stimulus
GO:0051594	IMP:UniProtKB	P	detection of glucose
GO:0031018	TAS:Reactome	P	endocrine pancreas development
GO:0006003	IEA:Ensembl	P	fructose 2,6-bisphosphate metabolic process
GO:0042593	IMP:UniProtKB	P	glucose homeostasis
GO:0006006	IEA:Ensembl	P	glucose metabolic process
GO:0015758	TAS:Reactome	P	glucose transport
GO:0005978	IEA:Ensembl	P	glycogen biosynthetic process
GO:0006096	IEA:UniProtKB-KW	P	glycolytic process
GO:0008645	TAS:Reactome	P	hexose transport
GO:0055088	IEA:Ensembl	P	lipid homeostasis
GO:0006739	IEA:Ensembl	P	NADP metabolic process
GO:0032811	IEA:Ensembl	P	negative regulation of epinephrine secretion
GO:0045721	IMP:UniProtKB	P	negative regulation of gluconeogenesis
GO:0007204	IEA:Ensembl	P	positive regulation of cytosolic calcium ion concentration
GO:0045725	IMP:UniProtKB	P	positive regulation of glycogen biosynthetic process
GO:0045821	IEA:Ensembl	P	positive regulation of glycolytic process
GO:0032024	IMP:UniProtKB	P	positive regulation of insulin secretion
GO:0042327	IEA:Ensembl	P	positive regulation of phosphorylation
GO:0010827	TAS:Reactome	P	regulation of glucose transport
GO:0006110	NAS:BHF-UCL	P	regulation of glycolytic process
GO:0050796	IMP:BHF-UCL	P	regulation of insulin secretion
GO:0043266	IEA:Ensembl	P	regulation of potassium ion transport
GO:0019932	IEA:Ensembl	P	second-messenger-mediated signaling
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0055085	TAS:Reactome	P	transmembrane transport

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111045	Developmental Biology
REACT_116125	Disease
REACT_212	Glucose transport
REACT_264090	Glycogen storage diseases
REACT_9441	Hexose transport
REACT_111217	Metabolism
REACT_474	Metabolism of carbohydrates
REACT_264430	Myoclonic epilepsy of Lafora
REACT_13698	Regulation of beta-cell development
REACT_13819	Regulation of gene expression in beta cells
REACT_6804	Regulation of Glucokinase by Glucokinase Regulatory Protein
REACT_19118	SLC-mediated transmembrane transport
REACT_15518	Transmembrane transport of small molecules

SMP Pathway Links

SMP ID	Description
SMP00043	Galactose Metabolism
SMP00182	Galactosemia
SMP00495	Galactosemia II (GALK)
SMP00496	Galactosemia III
SMP00553	Glycogenosis, Type III. Cori disease, Debrancher glycogenosis
SMP00554	Glycogenosis, Type IV. Amylopectinosis, Anderson disease
SMP00555	Glycogenosis, Type VI. Hers disease
SMP00552	Glycogen synthetase deficiency
SMP00556	Mucopolysaccharidosis VI. Sly syndrome
SMP00010	Nucleotide Sugars Metabolism
SMP00058	Starch and Sucrose Metabolism
SMP00557	Sucrase-isomaltase deficiency
SMP00467	Trehalose Degradation