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MGP001225

UniProt Annotations

Entry Information
Gene Namegolgi glycoprotein 1
Protein EntryGSLG1_HUMAN
UniProt IDQ92896
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92896-1; Sequence=Displayed; Name=2; IsoId=Q92896-2; Sequence=VSP_035998; Note=Contains a phosphoserine at position 1201.; Name=3; IsoId=Q92896-3; Sequence=VSP_043472, VSP_035998; Note=No experimental confirmation available. Contains a phosphoserine at position 1190.;
Developmental StageExpressed both in adult and fetal tissues.
FunctionBinds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils).
PtmFucosylation is essential for binding to E-selectin. {ECO:0000250}.
PtmN-glycosylated. Contains sialic acid residues (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAB02178.1; Type=Frameshift; Positions=27, 35; Evidence={ECO:0000305};
SimilarityContains 16 Cys-rich GLG1 repeats. {ECO:0000255|PROSITE-ProRule:PRU00622}.
Subcellular LocationGolgi apparatus membrane {ECO:0000269|PubMed:2355176}; Single-pass type I membrane protein {ECO:0000269|PubMed:2355176}.
Tissue SpecificityWidely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain. {ECO:0000269|PubMed:9182700}.
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