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MGP001235

Record overview

MGPD IDMGP001235
Gene ID2745
SpeciesHomo sapiens (Human)
Gene Nameglutaredoxin (thioltransferase)
Gene Symbol GLRX
SynonymsGRX; GRX1;
Alternate namesglutaredoxin-1; TTase-1; thioltransferase-1;
Chromosome5
Map Location5q14
SummaryThis gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for GLRX

Proteins

glutaredoxin-1
Refseq ID:NP_001112362
Protein GI:169646776
UniProt ID:P35754
mRNA ID:NM_001118890
Length:106
RefSeq Status:
MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLK
QIGALQ
 
glutaredoxin-1
Refseq ID:NP_002055
Protein GI:4504025
UniProt ID:P35754
mRNA ID:NM_002064
Length:106
RefSeq Status:
Protein sequence is identical to GI:169646776 (mRNA isoform)
 
glutaredoxin-1
Refseq ID:NP_001230588
Protein GI:343887376
UniProt ID:P35754
mRNA ID:NM_001243659
Length:106
RefSeq Status:
Protein sequence is identical to GI:169646776 (mRNA isoform)
 
glutaredoxin-1
Refseq ID:NP_001230587
Protein GI:343887374
UniProt ID:P35754
mRNA ID:NM_001243658
Length:106
RefSeq Status:
Protein sequence is identical to GI:169646776 (mRNA isoform)
 
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