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MGP001237

Record overview

MGPD IDMGP001237
Gene ID2752
SpeciesHomo sapiens (Human)
Gene Nameglutamate-ammonia ligase
Gene Symbol GLUL
SynonymsGS; GLNS; PIG43; PIG59;
Alternate namesglutamine synthetase; cell proliferation-inducing protein 59; glutamate decarboxylase; glutamine synthase; proliferation-inducing protein 43;
Chromosome1
Map Location1q31
EC Number6.3.1.2
SummaryThe protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
OrthologsView orthologs and multiple alignments for GLUL

Proteins

glutamine synthetase
Refseq ID:NP_002056
Protein GI:19923206
UniProt ID:P15104
mRNA ID:NM_002065
Length:373
RefSeq Status:
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCE
VFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPA
QWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
 
glutamine synthetase
Refseq ID:NP_001028228
Protein GI:74271826
UniProt ID:P15104
mRNA ID:NM_001033056
Length:373
RefSeq Status:
Protein sequence is identical to GI:19923206 (mRNA isoform)
 
glutamine synthetase
Refseq ID:NP_001028216
Protein GI:74271837
UniProt ID:P15104
mRNA ID:NM_001033044
Length:373
RefSeq Status:
Protein sequence is identical to GI:19923206 (mRNA isoform)
 
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