MGP Database

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MGP001240

UniProt Annotations

Entry Information
Gene Nameguanosine monophosphate reductase
Protein EntryGMPR1_HUMAN
UniProt IDP36959
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityInosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
CautionThe N-terminus was initially (PubMed:2758468) thought to be fused with glucose-6-phosphate-dehydrogenase (G6PD) protein in vivo. However, PubMed:2570640 showed that it encodes a GMP reductase, and PubMed:1694726 showed that the chimeric protein is an artifact. {ECO:0000305|PubMed:2758468}.
FunctionCatalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
PolymorphismAt least two different alleles are known.
SimilarityBelongs to the IMPDH/GMPR family. {ECO:0000305}.
SubunitHomotetramer. {ECO:0000269|Ref.8}.
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