MGP Database

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MGP001260

UniProt Annotations

Entry Information
Gene Nameguanine nucleotide binding protein (G protein), gamma 7
Protein EntryGBG7_HUMAN
UniProt IDO60262
SpeciesHuman
Comments
Comment typeDescription
FunctionGuanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity). {ECO:0000250}.
SimilarityBelongs to the G protein gamma family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
SubunitG proteins are composed of 3 units, alpha, beta and gamma.
Tissue SpecificityExpressed in a variety of tissues. Down- regulated in pancreatic and esophageal cancer. {ECO:0000269|PubMed:18219292}.
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