MGP Database

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MGP001277

Ontology/Pathway Information

Entrez Gene ID2817
Gene Nameglypican 1
Gene Symbol GPC1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031225 IEA:UniProtKB-KWCanchored component of membrane
GO:0005768 IEA:UniProtKB-SubCellCendosome
GO:0005615 TAS:ProtIncCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005796 TAS:ReactomeCGolgi lumen
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0043202 TAS:ReactomeClysosomal lumen
GO:0045121 ISS:UniProtKBCmembrane raft
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005578 ISS:UniProtKBCproteinaceous extracellular matrix
GO:0005507 IDA:UniProtKBFcopper ion binding
GO:0017134 ISS:UniProtKBFfibroblast growth factor binding
GO:0043236 ISS:UniProtKBFlaminin binding
GO:0007411 TAS:ReactomePaxon guidance
GO:0005975 TAS:ReactomePcarbohydrate metabolic process
GO:0030204 TAS:ReactomePchondroitin sulfate metabolic process
GO:0006024 TAS:ReactomePglycosaminoglycan biosynthetic process
GO:0006027 TAS:ReactomePglycosaminoglycan catabolic process
GO:0030203 TAS:ReactomePglycosaminoglycan metabolic process
GO:0030200 IDA:UniProtKBPheparan sulfate proteoglycan catabolic process
GO:0032288 ISS:UniProtKBPmyelin assembly
GO:0040037 ISS:UniProtKBPnegative regulation of fibroblast growth factor receptor signaling pathway
GO:0007603 TAS:ReactomePphototransduction, visible light
GO:2001016 ISS:UniProtKBPpositive regulation of skeletal muscle cell differentiation
GO:0001523 TAS:ReactomePretinoid metabolic process
GO:0014037 ISS:UniProtKBPSchwann cell differentiation
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_19226Activation of Rac
REACT_121408A tetrasaccharide linker sequence is required for GAG synthesis
REACT_18266Axon guidance
REACT_121206Chondroitin sulfate/dermatan sulfate metabolism
REACT_268678Defective B3GAT3 causes JDSSDHD
REACT_268431Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268749Defective B4GALT7 causes EDS, progeroid type
REACT_267917Defective CHST14 causes EDS, musculocontractural type
REACT_267648Defective CHST3 causes SEDCJD
REACT_268786Defective CHST6 causes MCDC1
REACT_268113Defective CHSY1 causes TPBS
REACT_267942Defective EXT1 causes exostoses 1, TRPS2 and CHDS
REACT_267741Defective EXT2 causes exostoses 2
REACT_268843Defective PAPSS2 causes SEMD-PA
REACT_268059Defective SLC26A2 causes chondrodysplasias
REACT_111045Developmental Biology
REACT_116125Disease
REACT_268624Diseases associated with glycosaminoglycan metabolism
REACT_160102Diseases associated with visual transduction
REACT_268324Diseases of glycosylation
REACT_264090Glycogen storage diseases
REACT_121315Glycosaminoglycan metabolism
REACT_121314Heparan sulfate/heparin (HS-GAG) metabolism
REACT_121248HS-GAG biosynthesis
REACT_120752HS-GAG degradation
REACT_19342Inactivation of Cdc42 and Rac
REACT_111217Metabolism
REACT_474Metabolism of carbohydrates
REACT_147857MPS I - Hurler syndrome
REACT_147734MPS II - Hunter syndrome
REACT_147753MPS IIIA - Sanfilippo syndrome A
REACT_147788MPS IIIB - Sanfilippo syndrome B
REACT_147860MPS IIIC - Sanfilippo syndrome C
REACT_147749MPS IIID - Sanfilippo syndrome D
REACT_147825MPS IV - Morquio syndrome A
REACT_147798MPS IV - Morquio syndrome B
REACT_147739MPS IX - Natowicz syndrome
REACT_147759MPS VII - Sly syndrome
REACT_147719MPS VI - Maroteaux-Lamy syndrome
REACT_147853Mucopolysaccharidoses
REACT_264430Myoclonic epilepsy of Lafora
REACT_24968Retinoid metabolism and transport
REACT_19230Role of Abl in Robo-Slit signaling
REACT_19351Signaling by Robo receptor
REACT_111102Signal Transduction
REACT_160125Visual phototransduction
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