Log in / Register

MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MGP001294

UniProt Annotations

Entry Information

Gene Name	G protein-coupled receptor 37 (endothelin receptor type B-like)
Protein Entry	GPR37_HUMAN
UniProt ID	O15354
Species	Human

Comments

Comment type	Description
Function	Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. {ECO:0000269\|PubMed:11439185, ECO:0000269\|PubMed:23690594, ECO:0000269\|PubMed:9526070}.
Ptm	Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. {ECO:0000269\|PubMed:17059562}.
Similarity	Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269\|PubMed:17059562}. Endoplasmic reticulum membrane {ECO:0000269\|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269\|PubMed:17059562}.
Subunit	Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2- mediated GPR37 ubiquitination. Interacts with PACRG. {ECO:0000269\|PubMed:11439185, ECO:0000269\|PubMed:12150907, ECO:0000269\|PubMed:14532270}.
Tissue Specificity	Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). {ECO:0000269\|PubMed:9526070}.