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MGP001302

UniProt Annotations

Entry Information
Gene Nameglutamic-pyruvate transaminase (alanine aminotransferase)
Protein EntryALAT1_HUMAN
UniProt IDP24298
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityL-alanine + 2-oxoglutarate = pyruvate + L- glutamate.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
FunctionCatalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}.
InductionBy glucocorticoids.
PathwayAmino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.
SimilarityBelongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer.
Tissue SpecificityLiver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue. {ECO:0000269|PubMed:11863375}.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPT";
Web ResourceName=Wikipedia; Note=Alanine transaminase entry; URL="http://en.wikipedia.org/wiki/Alanine_transaminase";
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