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MGP001304

UniProt Annotations

Entry Information
Gene Nameglutathione peroxidase 2 (gastrointestinal)
Protein EntryGPX2_HUMAN
UniProt IDP18283
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
FunctionCould play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
SimilarityBelongs to the glutathione peroxidase family. {ECO:0000305}.
Subcellular LocationCytoplasm. Note=Mainly cytoplasmic.
SubunitHomotetramer.
Tissue SpecificityMostly in liver and gastrointestinal tract, not found in heart or kidney.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx2/";
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