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MGP001306

Record overview

MGPD IDMGP001306
Gene ID2879
SpeciesHomo sapiens (Human)
Gene Nameglutathione peroxidase 4
Gene Symbol GPX4
SynonymsMCSP; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx;
Alternate namesphospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxidase; sperm nucleus glutathione peroxidase;
Chromosome19
Map Location19p13.3
EC Number1.11.1.12
SummaryThis gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
OrthologsView orthologs and multiple alignments for GPX4

Proteins

phospholipid hydroperoxide glutathione peroxidase, mitochondrial isoform A precursor
Refseq ID:NP_002076
Protein GI:75709200
UniProt ID:P36969
mRNA ID:NM_002085
Length:197
RefSeq Status:
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAF
PCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2509
peptide sequence: 
MSLGRLCRLLKPALLCGALAAPGLA
 
phospholipid hydroperoxide glutathione peroxidase, mitochondrial isoform B precursor
Refseq ID:NP_001034936
Protein GI:90903238
UniProt ID:P36969
mRNA ID:NM_001039847
Length:227
RefSeq Status:
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAF
PCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFGHRLSTVPHRQERLRGEALRTHGGAPGDREGP
APLFLAPQVCGPARAPAHALGAFHRHS
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2509
peptide sequence: 
MSLGRLCRLLKPALLCGALAAPGLA

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2509
peptide sequence: 
MSLGRLCRLLKPALLCGALAAPGLA
 
phospholipid hydroperoxide glutathione peroxidase, mitochondrial isoform C precursor
Refseq ID:NP_001034937
Protein GI:90903240
UniProt ID:Q6PI42
mRNA ID:NM_001039848
Length:234
RefSeq Status:
MGRAGAGSPGRRRQRCQSRGRRRPRAPRRRKAPACRRRRARRRRKKPCPRSLRPEIHECPKSQDPCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFV
CIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKW
NFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2509
peptide sequence: 
MSLGRLCRLLKPALLCGALAAPGLA
 
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