MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001307

UniProt Annotations

Entry Information
Gene Nameglutathione peroxidase 7
Protein EntryGPX7_HUMAN
UniProt IDQ96SL4
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
DiseaseBarrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269|PubMed:22157330}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.
FunctionIt protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. {ECO:0000269|PubMed:22157330}.
Sequence CautionSequence=AAC72961.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
SimilarityBelongs to the glutathione peroxidase family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000305}.
Tissue SpecificityExpressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids. {ECO:0000269|PubMed:22157330}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx7/";
  logo