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MGP001311

UniProt Annotations

Entry Information
Gene Namegrowth factor receptor-bound protein 14
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14449-1; Sequence=Displayed; Name=2; IsoId=Q14449-2; Sequence=VSP_056582, VSP_056583; Note=No experimental confirmation available.;
DomainThe PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3. {ECO:0000269|PubMed:19648926}.
FunctionAdapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
PtmPhosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2. {ECO:0000269|PubMed:20973951}.
SimilarityBelongs to the GRB7/10/14 family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 Ras-associating domain. {ECO:0000255|PROSITE-ProRule:PRU00166}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
SubunitInteracts with the cytoplasmic domain of the autophosphorylated insulin receptor (INSR), through the SH2 domain (By similarity). Interacts with GRB14 (via BPS domain); this interaction protects the tyrosines in the activation loop on INSR from dephosphorylation. Binds to the ankyrin repeat region of TNKS2 via its N-terminus. Interacts with activated NRAS. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). {ECO:0000250, ECO:0000269|PubMed:11726652, ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:16246733, ECO:0000269|PubMed:19648926, ECO:0000269|PubMed:20973951}.
Tissue SpecificityExpressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
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