MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001322

Ontology/Pathway Information

Entrez Gene ID2902
Gene Nameglutamate receptor, ionotropic, N-methyl D-aspartate 1
Gene Symbol GRIN1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0009986 ISS:BHF-UCLCcell surface
GO:0030425 IDA:UniProtKBCdendrite
GO:0032590 IEA:EnsemblCdendrite membrane
GO:0043197 ISS:BHF-UCLCdendritic spine
GO:0005783 IEA:EnsemblCendoplasmic reticulum
GO:0060076 ISS:BHF-UCLCexcitatory synapse
GO:0005887 IDA:UniProtKBCintegral component of plasma membrane
GO:0097481 IEA:EnsemblCneuronal postsynaptic density
GO:0043005 ISS:UniProtKBCneuron projection
GO:0017146 IDA:UniProtKBCN-methyl-D-aspartate selective glutamate receptor complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0014069 ISS:UniProtKBCpostsynaptic density
GO:0045211 ISS:UniProtKBCpostsynaptic membrane
GO:0045202 ISS:UniProtKBCsynapse
GO:0043083 ISS:BHF-UCLCsynaptic cleft
GO:0008021 ISS:UniProtKBCsynaptic vesicle
GO:0043195 ISS:BHF-UCLCterminal bouton
GO:0005262 IEA:EnsemblFcalcium channel activity
GO:0005509 ISS:UniProtKBFcalcium ion binding
GO:0005516 ISS:UniProtKBFcalmodulin binding
GO:0005234 IBA:GO_CentralFextracellular-glutamate-gated ion channel activity
GO:0016595 IDA:UniProtKBFglutamate binding
GO:0016594 IDA:UniProtKBFglycine binding
GO:0042165 ISS:BHF-UCLFneurotransmitter binding
GO:0004972 IEA:EnsemblFN-methyl-D-aspartate selective glutamate receptor activity
GO:0022843 IEA:EnsemblFvoltage-gated cation channel activity
GO:0008344 IEA:EnsemblPadult locomotory behavior
GO:0055074 ISS:UniProtKBPcalcium ion homeostasis
GO:0070588 IDA:GOCPcalcium ion transmembrane transport
GO:0006812 IDA:UniProtKBPcation transport
GO:0006874 IEA:EnsemblPcellular calcium ion homeostasis
GO:0071287 IEA:EnsemblPcellular response to manganese ion
GO:0021987 IEA:EnsemblPcerebral cortex development
GO:0001661 IEA:EnsemblPconditioned taste aversion
GO:0035235 ISS:UniProtKBPionotropic glutamate receptor signaling pathway
GO:0034220 IBA:GO_CentralPion transmembrane transport
GO:0007616 IEA:EnsemblPlong-term memory
GO:0060179 IEA:EnsemblPmale mating behavior
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0008355 IEA:EnsemblPolfactory learning
GO:0021586 IEA:EnsemblPpons maturation
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:2000463 ISS:BHF-UCLPpositive regulation of excitatory postsynaptic membrane potential
GO:0045944 ISS:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0060134 IEA:EnsemblPprepulse inhibition
GO:0018964 ISS:BHF-UCLPpropylene metabolic process
GO:0051262 IEA:EnsemblPprotein tetramerization
GO:0050770 IEA:EnsemblPregulation of axonogenesis
GO:0048814 IEA:EnsemblPregulation of dendrite morphogenesis
GO:0060079 ISS:UniProtKBPregulation of excitatory postsynaptic membrane potential
GO:0048169 IEA:EnsemblPregulation of long-term neuronal synaptic plasticity
GO:0042391 IDA:UniProtKBPregulation of membrane potential
GO:0043576 IEA:EnsemblPregulation of respiratory gaseous exchange
GO:0051963 IEA:EnsemblPregulation of synapse assembly
GO:0007585 IEA:EnsemblPrespiratory gaseous exchange
GO:0001975 IEA:EnsemblPresponse to amphetamine
GO:0051592 IEA:EnsemblPresponse to calcium ion
GO:0045471 IDA:UniProtKBPresponse to ethanol
GO:0060992 IEA:EnsemblPresponse to fungicide
GO:0043278 IEA:EnsemblPresponse to morphine
GO:0048511 IEA:EnsemblPrhythmic process
GO:0019233 IEA:EnsemblPsensory perception of pain
GO:0035176 IEA:EnsemblPsocial behavior
GO:0001967 IEA:EnsemblPsuckling behavior
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0035249 IBA:GO_CentralPsynaptic transmission, glutamatergic
GO:0008542 ISS:UniProtKBPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_18266Axon guidance
REACT_20642CREB phosphorylation through the activation of CaMKII
REACT_20568CREB phosphorylation through the activation of Ras
REACT_111045Developmental Biology
REACT_263952EPHB-mediated forward signaling
REACT_264068EPH-Ephrin signaling
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_20593Post NMDA receptor activation events
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_13477Transmission across Chemical Synapses
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00624Methadone Metabolism Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
  logo