MGP Database

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MGP001323

Ontology/Pathway Information

Entrez Gene ID2903
Gene Nameglutamate receptor, ionotropic, N-methyl D-aspartate 2A
Gene Symbol GRIN2A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0009986 ISS:BHF-UCLCcell surface
GO:0030425 IBA:GO_CentralCdendrite
GO:0005783 IEA:EnsemblCendoplasmic reticulum
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0097481 IEA:EnsemblCneuronal postsynaptic density
GO:0017146 IDA:UniProtKBCN-methyl-D-aspartate selective glutamate receptor complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0045211 IBA:GO_CentralCpostsynaptic membrane
GO:0042734 IEA:EnsemblCpresynaptic membrane
GO:0008021 IEA:EnsemblCsynaptic vesicle
GO:0005262 IEA:EnsemblFcalcium channel activity
GO:0005234 IBA:GO_CentralFextracellular-glutamate-gated ion channel activity
GO:0004972 IBA:GO_CentralFN-methyl-D-aspartate selective glutamate receptor activity
GO:0008270 ISS:UniProtKBFzinc ion binding
GO:0033058 IEA:EnsemblPdirectional locomotion
GO:0042417 IEA:EnsemblPdopamine metabolic process
GO:0007215 TAS:ProtIncPglutamate receptor signaling pathway
GO:0035235 IBA:GO_CentralPionotropic glutamate receptor signaling pathway
GO:0034220 IBA:GO_CentralPion transmembrane transport
GO:0007611 TAS:ProtIncPlearning or memory
GO:0007613 IEA:EnsemblPmemory
GO:0042177 IEA:EnsemblPnegative regulation of protein catabolic process
GO:0022008 IEA:EnsemblPneurogenesis
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0008104 IEA:EnsemblPprotein localization
GO:0060079 IEA:EnsemblPregulation of excitatory postsynaptic membrane potential
GO:0051930 IEA:EnsemblPregulation of sensory perception of pain
GO:0048167 IEA:EnsemblPregulation of synaptic plasticity
GO:0001975 IEA:EnsemblPresponse to amphetamine
GO:0042493 IEA:EnsemblPresponse to drug
GO:0045471 IDA:UniProtKBPresponse to ethanol
GO:0009611 IEA:EnsemblPresponse to wounding
GO:0019233 IEA:EnsemblPsensory perception of pain
GO:0042428 IEA:EnsemblPserotonin metabolic process
GO:0030431 IEA:EnsemblPsleep
GO:0001964 IEA:EnsemblPstartle response
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0035249 IBA:GO_CentralPsynaptic transmission, glutamatergic
GO:0006810 TAS:ProtIncPtransport
GO:0008542 IEA:EnsemblPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_20642CREB phosphorylation through the activation of CaMKII
REACT_20568CREB phosphorylation through the activation of Ras
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_20593Post NMDA receptor activation events
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_13477Transmission across Chemical Synapses
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00624Methadone Metabolism Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
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