MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001330

UniProt Annotations

Entry Information
Gene Nameglutamate receptor, metabotropic 3
Protein EntryGRM3_HUMAN
UniProt IDQ14832
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14832-1; Sequence=Displayed; Name=2; Synonyms=GRM3Delta4; IsoId=Q14832-2; Sequence=VSP_047679, VSP_047680; Note=Appears to be membrane-associated, despite the absence of the seven-transmembrane domain.;
FunctionG-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.
Sequence CautionSequence=AAD15616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 3 family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:8840013}; Multi-pass membrane protein {ECO:0000269|PubMed:8840013}.
SubunitInteracts with GRASP. {ECO:0000250}.
Tissue SpecificityDetected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. {ECO:0000269|PubMed:8840013}.
  logo