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MGP001346

UniProt Annotations

Entry Information
Gene Nameglutathione reductase
Protein EntryGSHR_HUMAN
UniProt IDP00390
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=5; Name=Mitochondrial; IsoId=P00390-1; Sequence=Displayed; Name=Cytoplasmic; IsoId=P00390-2; Sequence=VSP_018972; Note=Produced by alternative initiation of isoform Mitochondrial.; Name=2; Synonyms=delta8; IsoId=P00390-3; Sequence=VSP_042908; Name=3; Synonyms=delta9; IsoId=P00390-4; Sequence=VSP_042909; Note=Expressed at very high levels in peripheral blood.; Name=4; Synonyms=delta8+9; IsoId=P00390-5; Sequence=VSP_042908, VSP_042909;
Catalytic Activity2 glutathione + NADP(+) = glutathione disulfide + NADPH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
DomainEach subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface.
FunctionMaintains high levels of reduced glutathione in the cytosol.
MiscellaneousThe active site is a redox-active disulfide bond.
Sequence CautionSequence=AAP88037.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}.
Subcellular LocationIsoform Cytoplasmic: Cytoplasm.
Subcellular LocationIsoform Mitochondrial: Mitochondrion.
SubunitHomodimer; disulfide-linked. {ECO:0000269|PubMed:8626496}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gsr/";
Web ResourceName=Wikipedia; Note=Glutathione reductase entry; URL="http://en.wikipedia.org/wiki/Glutathione_reductase";
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