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MGP001352

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase mu 1
Protein EntryGSTM1_HUMAN
UniProt IDP09488
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09488-1; Sequence=Displayed; Name=2; IsoId=P09488-2; Sequence=VSP_036618;
Catalytic ActivityRX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:16548513}.
FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000269|PubMed:16548513}.
PolymorphismThere are two alleles; GSTM1A and GSTM1B which differ in position 173.
SimilarityBelongs to the GST superfamily. Mu family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer.
Tissue SpecificityLiver (at protein level). {ECO:0000269|PubMed:7822249}.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTM1";
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