MGP Database

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MGP001361

Ontology/Pathway Information

Entrez Gene ID2956
Gene NamemutS homolog 6
Gene Symbol MSH6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005794 IDA:HPACGolgi apparatus
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0032301 IDA:UniProtKBCMutSalpha complex
GO:0000790 IEA:EnsemblCnuclear chromatin
GO:0000228 IBA:GO_CentralCnuclear chromosome
GO:0005654 IDA:HPACnucleoplasm
GO:0005886 IDA:HPACplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0003682 IEA:EnsemblFchromatin binding
GO:0003684 IEA:EnsemblFdamaged DNA binding
GO:0008094 IBA:GO_CentralFDNA-dependent ATPase activity
GO:0032137 IEA:EnsemblFguanine/thymine mispair binding
GO:0035064 IDA:UniProtKBFmethylated histone binding
GO:0030983 IDA:UniProtKBFmismatched DNA binding
GO:0006200 IDA:GOCPATP catabolic process
GO:0008340 ISS:BHF-UCLPdetermination of adult lifespan
GO:0006281 IDA:BHF-UCLPDNA repair
GO:0097193 ISS:BHF-UCLPintrinsic apoptotic signaling pathway
GO:0008630 ISS:BHF-UCLPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0045190 ISS:BHF-UCLPisotype switching
GO:0000710 ISS:BHF-UCLPmeiotic mismatch repair
GO:0006298 IDA:UniProtKBPmismatch repair
GO:0045910 IDA:BHF-UCLPnegative regulation of DNA recombination
GO:0051096 IDA:BHF-UCLPpositive regulation of helicase activity
GO:0007131 IBA:GO_CentralPreciprocal meiotic recombination
GO:0009411 ISS:BHF-UCLPresponse to UV
GO:0016446 ISS:BHF-UCLPsomatic hypermutation of immunoglobulin genes
GO:0016447 ISS:BHF-UCLPsomatic recombination of immunoglobulin gene segments
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_216DNA Repair
REACT_264442Mismatch Repair
REACT_264501Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
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