MGP Database

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MGP001375

UniProt Annotations

Entry Information
Gene Namegeneral transcription factor IIIC, polypeptide 1, alpha 220kDa
Protein EntryTF3C1_HUMAN
UniProt IDQ12789
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12789-2; Sequence=Displayed; Name=2; IsoId=Q12789-3; Sequence=VSP_021819; Note=No experimental confirmation available.;
FunctionRequired for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
Sequence CautionSequence=AAA17985.1; Type=Frameshift; Positions=152, 189; Evidence={ECO:0000305}; Sequence=AAA85638.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential vector sequence at the N-terminus.; Evidence={ECO:0000305};
SimilarityBelongs to the TFIIIC subunit 1 family. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitPart of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2. {ECO:0000269|PubMed:19299493}.
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