MGP Database

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MGP001380

UniProt Annotations

Entry Information
Gene Nameguanylate cyclase 1, soluble, beta 3
Protein EntryGCYB1_HUMAN
UniProt IDQ02153
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=HSGC-1; IsoId=Q02153-1; Sequence=Displayed; Name=HSGC-2; IsoId=Q02153-2; Sequence=VSP_001813; Name=3; IsoId=Q02153-3; Sequence=VSP_054365; Note=No experimental confirmation available.;
Catalytic ActivityGTP = 3',5'-cyclic GMP + diphosphate.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250}; Note=Binds 1 or 2 heme groups per heterodimer. {ECO:0000250};
Enzyme RegulationActivated by nitric oxide in the presence of magnesium or manganese ions.
MiscellaneousThere are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
SimilarityBelongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
SimilarityContains 1 guanylate cyclase domain. {ECO:0000255|PROSITE-ProRule:PRU00099}.
Subcellular LocationCytoplasm.
SubunitHeterodimer of an alpha and a beta chain.
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