MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001391

UniProt Annotations

Entry Information
Gene NameH1 histone family, member 0
Protein EntryH10_HUMAN
UniProt IDP07305
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07305-1; Sequence=Displayed; Name=2; IsoId=P07305-2; Sequence=VSP_042163;
FunctionHistones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
InductionBoth the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level). {ECO:0000269|PubMed:18993075}.
InteractionP04014:E1 (xeno); NbExp=2; IntAct=EBI-725224, EBI-7014446;
PtmPhosphorylated on Ser-17 in RNA edited version.
Rna EditingModified_positions=Not_applicable; Note=Partially edited. In approximately 3.6% of the mRNA molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited version is called ET-H1.0. {ECO:0000269|PubMed:18993075};
SimilarityBelongs to the histone H1/H5 family. {ECO:0000255|PROSITE-ProRule:PRU00837}.
SimilarityContains 1 H15 (linker histone H1/H5 globular) domain. {ECO:0000255|PROSITE-ProRule:PRU00837}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00837, ECO:0000269|PubMed:18993075}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:18993075}. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
Web ResourceName=Wikipedia; Note=Histone H1 entry; URL="http://en.wikipedia.org/wiki/Histone_H1";
  logo