MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001406

Record overview

MGPD IDMGP001406
Gene ID3029
SpeciesHomo sapiens (Human)
Gene Namehydroxyacylglutathione hydrolase
Gene Symbol HAGH
SynonymsGLO2; GLX2; GLXII; HAGH1;
Alternate nameshydroxyacylglutathione hydrolase, mitochondrial; glx II; glyoxalase II; hydroxyacylglutathione hydroxylase;
Chromosome16
Map Location16p13.3
EC Number3.1.2.6
SummaryThe enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
OrthologsView orthologs and multiple alignments for HAGH

Proteins

hydroxyacylglutathione hydrolase, mitochondrial isoform 1 precursor
Refseq ID:NP_005317
Protein GI:94538322
UniProt ID:Q16775
mRNA ID:NM_005326
Length:308
RefSeq Status:
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLT
THHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEM
CKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREK
DQFKMPRD
 
transit_peptide: 1..33
calculated_mol_wt: 3280
peptide sequence: 
MVVGRGLLGRRSLAALGAACARRGLGPALLGVF

mat_peptide: 34..308
product: hydroxyacylglutathione hydrolase, mitochondrial isoform 1
calculated_mol_wt: 30544
peptide sequence: 
CHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGAL
THKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARH
VEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
 
hydroxyacylglutathione hydrolase, mitochondrial isoform 2
Refseq ID:NP_001035517
Protein GI:94538320
UniProt ID:Q16775
mRNA ID:NM_001040427
Length:260
RefSeq Status:
MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSL
NVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWA
KEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
 
transit_peptide: 1..33
calculated_mol_wt: 3280
peptide sequence: 
MVVGRGLLGRRSLAALGAACARRGLGPALLGVF

mat_peptide: 34..308
product: hydroxyacylglutathione hydrolase, mitochondrial isoform 1
calculated_mol_wt: 30544
peptide sequence: 
CHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGAL
THKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARH
VEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD

transit_peptide: 1..33
calculated_mol_wt: 3280
peptide sequence: 
MVVGRGLLGRRSLAALGAACARRGLGPALLGVF

mat_peptide: 34..236
product: hydroxyacylglutathione hydrolase, mitochondrial isoform 3
calculated_mol_wt: 22193
peptide sequence: 
CHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGAL
THKITHLSTLQVTPCLWLAAGSSMKGLRMRCVKLCWRSWAGSPRTQESTVATSTPSTTSSLHATWSPAMPPSGRSWPGPRRSTASGSPQCHPPWQRSLPT
TPS
 
hydroxyacylglutathione hydrolase, mitochondrial isoform 3 precursor
Refseq ID:NP_001273178
Protein GI:555943912
UniProt ID:Q16775
mRNA ID:NM_001286249
Length:236
RefSeq Status:
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLT
THHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVTPCLWLAAGSSMKGLRMRCVKLCWRSWAGSPRTQESTVATSTPSTTSSLHATWSP
AMPPSGRSWPGPRRSTASGSPQCHPPWQRSLPTTPS
 
transit_peptide: 1..33
calculated_mol_wt: 3280
peptide sequence: 
MVVGRGLLGRRSLAALGAACARRGLGPALLGVF

mat_peptide: 34..308
product: hydroxyacylglutathione hydrolase, mitochondrial isoform 1
calculated_mol_wt: 30544
peptide sequence: 
CHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGAL
THKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARH
VEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD

transit_peptide: 1..33
calculated_mol_wt: 3280
peptide sequence: 
MVVGRGLLGRRSLAALGAACARRGLGPALLGVF

mat_peptide: 34..236
product: hydroxyacylglutathione hydrolase, mitochondrial isoform 3
calculated_mol_wt: 22193
peptide sequence: 
CHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGAL
THKITHLSTLQVTPCLWLAAGSSMKGLRMRCVKLCWRSWAGSPRTQESTVATSTPSTTSSLHATWSPAMPPSGRSWPGPRRSTASGSPQCHPPWQRSLPT
TPS
 
  logo