MGP Database

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MGP001407

Ontology/Pathway Information

Entrez Gene ID3030
Gene Namehydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Gene Symbol HADHA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016507 IEA:InterProCmitochondrial fatty acid beta-oxidation multienzyme complex
GO:0005743 TAS:ReactomeCmitochondrial inner membrane
GO:0042645 IDA:BHF-UCLCmitochondrial nucleoid
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0003857 TAS:ProtIncF3-hydroxyacyl-CoA dehydrogenase activity
GO:0003985 TAS:ProtIncFacetyl-CoA C-acetyltransferase activity
GO:0004300 TAS:ProtIncFenoyl-CoA hydratase activity
GO:0000062 IEA:EnsemblFfatty-acyl-CoA binding
GO:0016509 IEA:UniProtKB-ECFlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016508 IEA:EnsemblFlong-chain-enoyl-CoA hydratase activity
GO:0051287 IEA:EnsemblFNAD binding
GO:0035965 TAS:ReactomePcardiolipin acyl-chain remodeling
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0006635 TAS:ReactomePfatty acid beta-oxidation
GO:0046474 TAS:ReactomePglycerophospholipid biosynthetic process
GO:0006644 TAS:ReactomePphospholipid metabolic process
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032868 IEA:EnsemblPresponse to insulin
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_121006Acyl chain remodeling of CL
REACT_1708Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
REACT_1887Beta oxidation of hexanoyl-CoA to butanoyl-CoA
REACT_735Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
REACT_2108Beta oxidation of myristoyl-CoA to lauroyl-CoA
REACT_1697Beta oxidation of octanoyl-CoA to hexanoyl-CoA
REACT_2025Beta oxidation of palmitoyl-CoA to myristoyl-CoA
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_121401Glycerophospholipid biosynthesis
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_1473Mitochondrial Fatty Acid Beta-Oxidation
REACT_1541mitochondrial fatty acid beta-oxidation of saturated fatty acids
REACT_120870Phospholipid metabolism
SMP Pathway Links
SMP IDDescription
SMP00538Carnitine palmitoyl transferase deficiency (I)
SMP00541Carnitine palmitoyl transferase deficiency (II)
SMP00181Ethylmalonic Encephalopathy
SMP00054Fatty Acid Elongation In Mitochondria
SMP00051Fatty acid Metabolism
SMP00185Glutaric Aciduria Type I
SMP00544Long-chain-3-hydroxyacyl-coa dehydrogenase deficiency (LCHAD)
SMP00539Long chain acyl-CoA dehydrogenase deficiency (LCAD)
SMP00542Medium chain acyl-coa dehydrogenase deficiency (MCAD)
SMP00482Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
SMP00481Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids
SMP00235Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency)
SMP00545Trifunctional protein deficiency
SMP00635Valproic Acid Metabolism Pathway
SMP00540Very-long-chain acyl coa dehydrogenase deficiency (VLCAD)
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