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MGP001414

Record overview

MGPD IDMGP001414
Gene ID3039
SpeciesHomo sapiens (Human)
Gene Namehemoglobin, alpha 1
Gene Symbol HBA1
SynonymsHBH; HBA-T3;
Alternate nameshemoglobin subunit alpha; alpha one globin; alpha-1 globin; alpha-1-globin; alpha-2 globin chain; alpha-globin; delta globin; hemoglobin alpha 1 globin chain; hemoglobin alpha chain; hemoglobin alpha-1 chain;
Chromosome16
Map Location16p13.3
SummaryThe human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HBA1

Proteins

hemoglobin subunit alpha
Refseq ID:NP_000549
Protein GI:4504347
UniProt ID:P69905
mRNA ID:NM_000558
Length:142
RefSeq Status:
MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFK
LLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR
 
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