MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001416

Record overview

MGPD IDMGP001416
Gene ID3043
SpeciesHomo sapiens (Human)
Gene Namehemoglobin, beta
Gene Symbol HBB
SynonymsCD113t-C; beta-globin;
Alternate nameshemoglobin subunit beta; beta globin chain; hemoglobin beta chain;
Chromosome11
Map Location11p15.5
SummaryThe alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HBB

Proteins

hemoglobin subunit beta
Refseq ID:NP_000509
Protein GI:4504349
UniProt ID:P68871
mRNA ID:NM_000518
Length:147
RefSeq Status:
MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVD
PENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH
 
  logo