MGP Database

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MGP001427

Ontology/Pathway Information

Entrez Gene ID3065
Gene Namehistone deacetylase 1
Gene Symbol HDAC1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000785 IDA:ParkinsonsUK-UCLCchromatin
GO:0005737 TAS:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0000118 TAS:UniProtKBChistone deacetylase complex
GO:0000790 IDA:UniProtKBCnuclear chromatin
GO:0005654 IDA:UniProtKBCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0016581 IDA:UniProtKBCNuRD complex
GO:0043234 IDA:UniProtKBCprotein complex
GO:0016580 IDA:BHF-UCLCSin3 complex
GO:0033613 IPI:UniProtKBFactivating transcription factor binding
GO:0001047 IDA:UniProtKBFcore promoter binding
GO:0019213 ISS:UniProtKBFdeacetylase activity
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0004407 IMP:UniProtKBFhistone deacetylase activity
GO:0042826 IPI:BHF-UCLFhistone deacetylase binding
GO:0032041 IEA:UniProtKB-ECFNAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0097372 IEA:UniProtKB-ECFNAD-dependent histone deacetylase activity (H3-K18 specific)
GO:0046969 IEA:UniProtKB-ECFNAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA:UniProtKB-ECFNAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0033558 IDA:UniProtKBFprotein deacetylase activity
GO:0047485 IDA:MGIFprotein N-terminus binding
GO:0070491 IPI:ParkinsonsUK-UCLFrepressing transcription factor binding
GO:0001103 IPI:BHF-UCLFRNA polymerase II repressing transcription factor binding
GO:0001106 IDA:BHF-UCLFRNA polymerase II transcription corepressor activity
GO:0003700 TAS:ProtIncFsequence-specific DNA binding transcription factor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0044212 IDA:ParkinsonsUK-UCLFtranscription regulatory region DNA binding
GO:0000976 ISS:UniProtKBFtranscription regulatory region sequence-specific DNA binding
GO:0043044 IDA:UniProtKBPATP-dependent chromatin remodeling
GO:0007596 TAS:ReactomePblood coagulation
GO:0016568 TAS:UniProtKBPchromatin modification
GO:0006338 IC:BHF-UCLPchromatin remodeling
GO:0032922 ISS:UniProtKBPcircadian regulation of gene expression
GO:0042733 ISS:BHF-UCLPembryonic digit morphogenesis
GO:0009913 ISS:BHF-UCLPepidermal cell differentiation
GO:0061029 ISS:BHF-UCLPeyelid development in camera-type eye
GO:0061198 ISS:BHF-UCLPfungiform papilla formation
GO:0010467 TAS:ReactomePgene expression
GO:0060789 ISS:BHF-UCLPhair follicle placode formation
GO:0016575 IMP:UniProtKBPhistone deacetylation
GO:0070932 IDA:BHF-UCLPhistone H3 deacetylation
GO:0070933 IDA:BHF-UCLPhistone H4 deacetylation
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0043922 IMP:UniProtKBPnegative regulation by host of viral transcription
GO:0060766 IDA:BHF-UCLPnegative regulation of androgen receptor signaling pathway
GO:0043066 ISS:BHF-UCLPnegative regulation of apoptotic process
GO:0045786 TAS:ReactomePnegative regulation of cell cycle
GO:0045892 IMP:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0042475 ISS:BHF-UCLPodontogenesis of dentin-containing tooth
GO:0008284 IMP:BHF-UCLPpositive regulation of cell proliferation
GO:0010870 IMP:BHF-UCLPpositive regulation of receptor biosynthetic process
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0006476 IDA:UniProtKBPprotein deacetylation
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_264165Chromatin modifying enzymes
REACT_264155Chromatin organization
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_264178deactivation of the beta-catenin transactivating complex
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_116125Disease
REACT_121111Downregulation of SMAD2/3:SMAD4 transcriptional activity
REACT_264098Epigenetic regulation of gene expression
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_264242formation of the beta-catenin:TCF transactivating complex
REACT_111214G0 and Early G1
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_263923HDACs deacetylate histones
REACT_604Hemostasis
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_21267Mitotic G1-G1/S phases
REACT_264000Negative epigenetic regulation of rRNA expression
REACT_263965NoRC negatively regulates rRNA expression
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_13695p75NTR negatively regulates cell cycle via SC1
REACT_13776p75 NTR receptor-mediated signalling
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_264567repression of WNT target genes
REACT_1974RNA Polymerase I Promoter Clearance
REACT_21352RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_1309RNA Polymerase I Transcription
REACT_953RNA Polymerase I Transcription Initiation
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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