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MGP001429

UniProt Annotations

Entry Information
Gene Namehistidine decarboxylase
Protein EntryDCHS_HUMAN
UniProt IDP19113
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P19113-1; Sequence=Displayed; Name=2; IsoId=P19113-2; Sequence=VSP_056296; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.1 mM for histidine {ECO:0000269|PubMed:22767596}; Vmax=1880 nmol/min/mg enzyme {ECO:0000269|PubMed:22767596};
Catalytic ActivityL-histidine = histamine + CO(2). {ECO:0000269|PubMed:22767596}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:22767596};
FunctionCatalyzes the biosynthesis of histamine from histidine. {ECO:0000269|PubMed:22767596}.
PathwayAmine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.
SimilarityBelongs to the group II decarboxylase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:22767596}.
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