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MGP001435

UniProt Annotations

Entry Information
Gene Namehepatocyte growth factor (hepapoietin A; scatter factor)
Protein EntryHGF_HUMAN
UniProt IDP14210
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=P14210-1; Sequence=Displayed; Name=2; IsoId=P14210-2; Sequence=VSP_009622, VSP_009623; Name=3; IsoId=P14210-3; Sequence=VSP_009617; Name=4; Synonyms=HGF/NK2; IsoId=P14210-4; Sequence=VSP_009620, VSP_009621; Note=Acts as a competitive antagonist in MET-signaling.; Name=5; IsoId=P14210-5; Sequence=VSP_009617, VSP_009622, VSP_009623; Note=No experimental confirmation available.; Name=6; Synonyms=HGF/NK1; IsoId=P14210-6; Sequence=VSP_009618, VSP_009619;
CautionHas lost two of the three essential catalytic residues and so probably has no enzymatic activity. {ECO:0000305}.
DiseaseDeafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:19576567}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionPotent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. {ECO:0000269|PubMed:15167892, ECO:0000269|PubMed:20624990}.
InteractionP08581:MET; NbExp=4; IntAct=EBI-1039104, EBI-1039152; P16056:Met (xeno); NbExp=2; IntAct=EBI-1039104, EBI-1798780;
SimilarityBelongs to the peptidase S1 family. Plasminogen subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 PAN domain. {ECO:0000255|PROSITE- ProRule:PRU00315}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
SimilarityContains 4 kringle domains. {ECO:0000255|PROSITE- ProRule:PRU00121}.
SubunitDimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity. {ECO:0000269|PubMed:15167892, ECO:0000269|PubMed:22242148}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HGFID385ch7q21.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hgf/";
Web ResourceName=Wikipedia; Note=Hepatocyte growth factor entry; URL="http://en.wikipedia.org/wiki/Hepatocyte_growth_factor";
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