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MGP001449

Record overview

MGPD IDMGP001449
Gene ID3115
SpeciesHomo sapiens (Human)
Gene Namemajor histocompatibility complex, class II, DP beta 1
Gene Symbol HLA-DPB1
SynonymsDPB1; HLA-DP; HLA-DPB; HLA-DP1B;
Alternate namesHLA class II histocompatibility antigen, DP beta 1 chain; HLA DP14-beta chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA-DP histocompatibility type, beta-1 subunit; MHC HLA DPB1; MHC class II HLA-DP-beta-1; MHC class II HLA-DRB1; MHC class II antigen DP beta 1 chain; MHC class II antigen DPB1; MHC class II antigen DPbeta1; MHC class II antigen beta chain; beta1 domain MHC class II HLA DPB; class II HLA beta chain; major histocompatibility complex class II antigen beta chain;
Chromosome6
Map Location6p21.3
SummaryHLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HLA-DPB1

Proteins

HLA class II histocompatibility antigen, DP beta 1 chain precursor
Refseq ID:NP_002112
Protein GI:24797076
UniProt ID:P04440
mRNA ID:NM_002121
Length:258
RefSeq Status:
MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRFLERYIYNREEFARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRA
VPDRMCRHNYELGGPMTLQRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYTC
QVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLIICGVGIFMHRRSKKVQRGSA
 
sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3014
peptide sequence: 
MMVLQVSAAPRTVALTALLMVLLTSVVQG

mat_peptide: 30..258
product: HLA class II histocompatibility antigen, DP beta 1 chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P04440.1)
calculated_mol_wt: 26164
peptide sequence: 
RATPENYLFQGRQECYAFNGTQRFLERYIYNREEFARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTLQRRVQPRVNVS
PSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTG
AGGFVLGLIICGVGIFMHRRSKKVQRGSA
 
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