MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001450

Record overview

MGPD IDMGP001450
Gene ID3117
SpeciesHomo sapiens (Human)
Gene Namemajor histocompatibility complex, class II, DQ alpha 1
Gene Symbol HLA-DQA1
SynonymsCD; GSE; DQ-A1; CELIAC1; HLA-DQA;
Alternate namesHLA class II histocompatibility antigen, DQ alpha 1 chain; DC-1 alpha chain; DC-alpha; HLA class II histocompatibility antigen, DQ(W3) alpha chain; HLA-DCA; MHC HLA-DQ alpha; MHC class II DQA1; MHC class II HLA-D alpha glycoprotein; MHC class II HLA-DQ-alpha-1; MHC class II antigen; MHC class II surface glycoprotein; leucocyte antigen DQA1; leukocyte antigen alpha chain;
Chromosome6
Map Location6p21.3
SummaryHLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HLA-DQA1

Proteins

HLA class II histocompatibility antigen, DQ alpha 1 chain precursor
Refseq ID:NP_002113
Protein GI:18426975
UniProt ID:P01909
mRNA ID:NM_002122
Length:255
RefSeq Status:
MILNKALLLGALALTTVMSPCGGEDIVADHVASCGVNLYQFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPEFSKFGGFDPQGALRNMAVAKHNLNIMI
KRYNSTAATNEVPEVTVFSKSPVTLGQPNTLICLVDNIFPPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFKISYLTFLPSADEIYDCKVEHWGLDQPL
LKHWEPEIPAPMSELTETVVCALGLSVGLMGIVVGTVFIIQGLRSVGASRHQGPL
 
sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2288
peptide sequence: 
MILNKALLLGALALTTVMSPCGG
 
  logo