MGP Database

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MGP001455

Ontology/Pathway Information

Entrez Gene ID3123
Gene Namemajor histocompatibility complex, class II, DR beta 1
Gene Symbol HLA-DRB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030669 TAS:ReactomeCclathrin-coated endocytic vesicle membrane
GO:0030666 TAS:ReactomeCendocytic vesicle membrane
GO:0012507 TAS:ReactomeCER to Golgi transport vesicle membrane
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0071556 TAS:ReactomeCintegral component of lumenal side of endoplasmic reticulum membrane
GO:0031902 IDA:UniProtKBClate endosome membrane
GO:0005765 IDA:UniProtKBClysosomal membrane
GO:0042613 IDA:UniProtKBCMHC class II protein complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0032588 TAS:ReactomeCtrans-Golgi network membrane
GO:0030658 TAS:ReactomeCtransport vesicle membrane
GO:0042605 IDA:UniProtKBFpeptide antigen binding
GO:0019886 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0002455 IDA:UniProtKBPhumoral immune response mediated by circulating immunoglobulin
GO:0002381 IDA:UniProtKBPimmunoglobulin production involved in immunoglobulin mediated immune response
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0002503 IDA:UniProtKBPpeptide antigen assembly with MHC class II protein complex
GO:0031295 TAS:ReactomePT cell costimulation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_19344Costimulation by the CD28 family
REACT_75790Cytokine Signaling in Immune system
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_6900Immune System
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_121399MHC class II antigen presentation
REACT_19324PD-1 signaling
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12526TCR signaling
REACT_12596Translocation of ZAP-70 to Immunological synapse
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