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MGP001470

UniProt Annotations

Entry Information
Gene Namehyaluronan-mediated motility receptor (RHAMM)
Protein EntryHMMR_HUMAN
UniProt IDO75330
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=O75330-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=O75330-2; Sequence=VSP_004286; Name=3; IsoId=O75330-3; Sequence=VSP_038378; Name=4; IsoId=O75330-4; Sequence=VSP_041266;
FunctionInvolved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity.
Subcellular LocationCell surface. Cytoplasm {ECO:0000250}.
SubunitSubunit of the HARC complex.
Tissue SpecificityExpressed in breast cancer cell lines and in normal breast tissue.
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