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MGP001489

UniProt Annotations

Entry Information
Gene Nameheterogeneous nuclear ribonucleoprotein L
Protein EntryHNRPL_HUMAN
UniProt IDP14866
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14866-1; Sequence=Displayed; Name=2; IsoId=P14866-2; Sequence=VSP_044301;
DomainRRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre- mRNA (PubMed:23782695). {ECO:0000269|PubMed:23782695}.
FunctionSplicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. {ECO:0000269|PubMed:11809897}.
MiscellaneousExcess hnRNP L activates NMD of its own mRNA by promoting the inclusion of a 'poison exon' containing a premature stop codon and leading to nonsense-mediated decay. It also cross- regulates inclusion of an analogous 'poison exon' in the hnRNP L- like pre-mRNA (PubMed:19124611). {ECO:0000305|PubMed:19124611}.
PtmPhosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization. {ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:22570490}.
PtmSeveral isoelectric forms of the L protein are probably the results of post-translational modifications.
Sequence CautionSequence=CAA34261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityContains 4 RRM (RNA recognition motif) domains. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular LocationNucleus, nucleoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
SubunitIdentified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRNPLL. Interacts with APEX1; the interaction is DNA-dependent. Component of a complex with SETD2. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18669861, ECO:0000269|PubMed:19332550}.
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