MGP Database

MGP001495

Ontology/Pathway Information

Entrez Gene ID	3251
Gene Name	hypoxanthine phosphoribosyltransferase 1
Gene Symbol	HPRT1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	IBA:GO_Central	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0052657	IDA:UniProtKB	F	guanine phosphoribosyltransferase activity
GO:0004422	IDA:UniProtKB	F	hypoxanthine phosphoribosyltransferase activity
GO:0000287	IDA:UniProtKB	F	magnesium ion binding
GO:0000166	IEA:UniProtKB-KW	F	nucleotide binding
GO:0042803	IPI:UniProtKB	F	protein homodimerization activity
GO:0006168	IBA:GO_Central	P	adenine salvage
GO:0021954	IEA:Ensembl	P	central nervous system neuron development
GO:0021895	IEA:Ensembl	P	cerebral cortex neuron differentiation
GO:0019835	IEA:Ensembl	P	cytolysis
GO:0048813	IEA:Ensembl	P	dendrite morphogenesis
GO:0042417	IEA:Ensembl	P	dopamine metabolic process
GO:0046038	IDA:UniProtKB	P	GMP catabolic process
GO:0032263	IBA:GO_Central	P	GMP salvage
GO:0007625	IEA:Ensembl	P	grooming behavior
GO:0006178	IDA:UniProtKB	P	guanine salvage
GO:0046100	IMP:UniProtKB	P	hypoxanthine metabolic process
GO:0043103	IDA:UniProtKB	P	hypoxanthine salvage
GO:0046040	IDA:UniProtKB	P	IMP metabolic process
GO:0032264	IBA:GO_Central	P	IMP salvage
GO:0007626	IEA:Ensembl	P	locomotory behavior
GO:0046651	IEA:Ensembl	P	lymphocyte proliferation
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:0045964	IMP:UniProtKB	P	positive regulation of dopamine metabolic process
GO:0051289	IDA:UniProtKB	P	protein homotetramerization
GO:0043101	TAS:Reactome	P	purine-containing compound salvage
GO:0006144	TAS:Reactome	P	purine nucleobase metabolic process
GO:0006164	IMP:UniProtKB	P	purine nucleotide biosynthetic process
GO:0006166	IMP:UniProtKB	P	purine ribonucleoside salvage
GO:0001975	IEA:Ensembl	P	response to amphetamine
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0021756	IEA:Ensembl	P	striatum development

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_1698	Metabolism of nucleotides
REACT_522	Purine metabolism
REACT_1923	Purine salvage

SMP Pathway Links

SMP ID	Description
SMP00535	Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144	Adenosine Deaminase Deficiency
SMP00167	Adenylosuccinate Lyase Deficiency
SMP00168	AICA-Ribosiduria
SMP00427	Azathioprine Action Pathway
SMP00365	Gout or Kelley-Seegmiller Syndrome
SMP00364	Lesch-Nyhan Syndrome (LNS)
SMP00428	Mercaptopurine Action Pathway
SMP00609	Mercaptopurine Metabolism Pathway
SMP00536	Mitochondrial DNA depletion syndrome
SMP00203	Molybdenum Cofactor Deficiency
SMP00537	Myoadenylate deaminase deficiency
SMP00050	Purine Metabolism
SMP00210	Purine Nucleoside Phosphorylase Deficiency
SMP00430	Thioguanine Action Pathway
SMP00647	Thioguanine Metabolism Pathway
SMP00220	Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512	Xanthinuria type I
SMP00513	Xanthinuria type II