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MGP001515

UniProt Annotations

Entry Information
Gene Nameheat shock 70kDa protein 2
Protein EntryHSP72_HUMAN
UniProt IDP54652
SpeciesHuman
Comments
Comment typeDescription
FunctionIn cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
InteractionQ96BE0:-; NbExp=2; IntAct=EBI-356991, EBI-9356686; O95429:BAG4; NbExp=2; IntAct=EBI-356991, EBI-2949658; Q9NZL4:HSPBP1; NbExp=3; IntAct=EBI-356991, EBI-356763;
SimilarityBelongs to the heat shock protein 70 family. {ECO:0000305}.
SubunitInteracts with ZNF541. Component of the CatSper complex (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with FKBP6. {ECO:0000250, ECO:0000269|PubMed:18529014, ECO:0000269|PubMed:20072699}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hspa2/";
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